Exposure-related conditions are a constant reality faced by homeless individuals who spend most days and many nights outside. Without shelter against the elements, they are dependent on mild temperatures and dry weather for a tolerable existence. And while some people who live on the streets may have tents or cardboard structures to provide a modicum of protection and privacy, they are still susceptible to hypo- or hyperthermia as well as associated maladies including frostbite, sunburn, and heat exhaustion. Those who are very young, old, malnourished or exhausted are at increased risk of serious health problems from exposure to temperature extremes. This issue discusses signs and symptoms of cold- and heat-related pathologies and how to prevent them.